1. The Dutch Hypothesis and British Hypothesis

The British hypothesis revisited.

Forty years ago, British investigators developed the hypothesis that recurrent bronchial infections were the reason that some smokers developed progressive airways obstruction and other did not [1]. The classical studies of FLETCHER et al. [2] were designed to test this proposition. They carried out a prospective study of working males, noting the frequency of respiratory infections, sputum qua...

Towards testing the Dutch hypothesis from childhood.

The Dutch hypothesis (chronic non-specific lung disease) revisited.

In 1961 the hypothesis (later referred to as the Dutch Hypothesis (DH)) was put forward that asthma, chronic bronchitis and emphysema should be considered as different expressions of one disease entity, in which both endogenous (host) and exogenous (environmental) factors play a role in the pathogenesis. A hereditary predisposition to develop allergy and bronchial hyperreactivity were considere...

Update on the "Dutch hypothesis" for chronic respiratory disease.

BACKGROUND Many patients with chronic obstructive lung disease show increased airways responsiveness to histamine. We investigated the hypothesis that increased airways responsiveness predicts the development and remission of chronic respiratory symptoms. METHODS We used data from 24-year follow-up (1965-90) of 2684 participants in a cohort study in Vlagtwedde and Vlaardingen, Netherlands. In...

HYPOTHESIS TESTING FOR AN EXCHANGEABLE NORMAL DISTRIBUTION

Consider an exchangeable normal vector with parameters ????2, and ?. On the basis of a vector observation some tests about these parameters are found and their properties are discussed. A simulation study for these tests and a few nonparametric tests are presented. Some advantages and disadvantages of these tests are discussed and a few applications are given.